Ehlers-Danlos syndrome Overview, Types, and Causes | MD Genetic Clinic 

At MD Genetic Clinic, we specialize in diagnosing and managing Ehlers-Danlos Syndrome (EDS), a group of rare genetic connective tissue disorders. Our board-certified geneticist provides personalized evaluation for both children and adults.

What is Ehlers-Danlos Syndrome?

Ehlers-Danlos Syndrome (EDS)  is a group of inherited conditions caused by changes in the genes responsible for collagen production. Collagen is one of the body’s primary structural proteins, providing strength and flexibility to connective tissue.

When collagen is weakened, connective tissues — including skin, joints, and blood vessels — may become more flexible, fragile, or prone to injury. Because connective tissue exists throughout the body, EDS can affect multiple systems at once.

Types of Ehlers-Danlos Syndrome

There are 13 recognized types of EDS, each with unique features.

• Common forms – often involve hypermobile joints, chronic pain, and fragile skin.

• Rare forms, like vascular EDS, can cause life-threatening complications such as blood vessel rupture.

Your type of EDS can often be identified by combining a detailed clinical evaluation with genetic testing.

Causes of Ehlers-Danlos Syndrome

EDS is caused by genetic mutations that affect collagen. These mutations can be:

• Inherited from a parent.

• Spontaneous, occurring without a family history.

Family members of someone with EDS may benefit from genetic counseling to assess their own risk.

Next: Read about Ehlers Danlos Syndrome Diagnosis and Treatment