Cancer Genetic Overview | Florida MD Genetic Clinic 

At MD Genetic Clinic in Florida, we help individuals and families understand their cancer risk, decide on appropriate genetic testing, and take informed steps for prevention and treatment. Our approach follows the National Comprehensive Cancer Network (NCCN) Guidelines to ensure every patient receives evidence-based care.

What is the difference between herideteray cancer and sporadic cancer ? 

Most cancers occur by chance (sporadic), caused by random DNA changes over time.
However, 5–10% of cancers are hereditary, caused by gene mutations passed from parent to child.

You may be at higher risk for hereditary cancer if:

• Multiple relatives have the same or related cancers

• Cancer developed at a younger age than usual (e.g., breast cancer before 50)

• Rare cancers occurred in your family (male breast cancer, ovarian cancer)

• There are multiple types of cancer in one person

At MD Genetic Clinic, we review your personal and family history in detail to determine if you meet NCCN criteria for genetic testing.

Who should consider genetic testing for cancer risk ? 

According to NCCN Guidelines, genetic testing is recommended if you have:

• Personal history of breast, ovarian, pancreatic, prostate, or colorectal cancer at a young age

• Multiple relatives with the same type of cancer

• Known mutation in the family (e.g., BRCA1, BRCA2, Lynch syndrome genes)

• Certain rare tumors (e.g., medullary thyroid cancer, pheochromocytoma)

At our Florida clinic, we:

• Review your medical and family history

• Determine if you meet NCCN testing criteria

• Recommend the most appropriate test (single gene, panel, or whole genome)

• Provide counseling before and after results

What are the most common heridetery cancer syndrome ? 

Some of the most common include:

• Hereditary Breast and Ovarian Cancer Syndrome – BRCA1 & BRCA2

• Lynch Syndrome – MLH1, MSH2, MSH6, PMS2, EPCAM

• Li-Fraumeni Syndrome – TP53 gene

• Other important genes – PALB2, CHEK2, ATM, CDH1, and more

If you test positive for one of these, we use NCCN guidelines to create a personalized screening and prevention plan for you and your family.

What happens if I test positive for a cancer related gene mutation ? 

A positive test means you have a higher lifetime risk for certain cancers — but it does not mean you currently have cancer.

Your plan may include:

• Earlier and more frequent screening (e.g., annual breast MRI starting at age 25 for BRCA carriers)

• Preventive surgery (risk-reducing mastectomy or oophorectomy)

• Family testing so relatives can take preventive steps

• Lifestyle modifications to reduce risk

Our team at MD Genetic Clinic will guide you through every option and coordinate with your other healthcare providers.

How does genetic testing help with cancer treatment?

Genetic results can guide treatment decisions:

• If you have a BRCA mutation, certain PARP inhibitors may be more effective.

• If you have Lynch syndrome, immunotherapy may be an option.

• Tumor testing (somatic mutations) can match you to targeted therapies or clinical trials.

We work closely with oncologists in Florida to ensure your results are integrated into your care plan.

Why Choose MD Genetic Clinic for Cancer Genetics in Florida?

• Board-certified MD  geneticist with over 10 years of  expertise in hereditary cancer syndromes

• Testing and counseling based on current NCCN guidelines

• Access to multiple testing laboratories to fit your insurance and budget

• Convenient telehealth appointments available throughout Florida